High Density Cobalt

Cobalt chelates recognize two exposed vicinal histidines. This resin is used in many purifications because this cation provides very good selectivity.High Density Cobalt provides a high amount of available groups allowing for higher binding capacity.The resin is adequate to work in batch or column purifications (Low Flow).

REFERENCES:

  • Muñoz-Morales, Emilio et al. “Deciphering the Effect of Microbead Size Distribution on the Kinetics of Heterogeneous Biocatalysts through Single-Particle Analysis Based on Fluorescence Microscopy.” Catalysts 9.11 (2019): n. pag. Catalysts. 
  • Anderson, Cathy J. et al. “Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.” Cell Reports 26.7 (2019): 1681-1690.e5. Cell Reports.
  • Product Name High Density Cobalt
  • Cat. No. 6BCL-QHCo-X
  • Bead Geometry & Size Spherical
  • Crosslinked Yes
  • Agarose % 6 %
  • Antimicrobial Agent 20% Ethanol
  • Storage Temperature 2-8˚C
  • Standard ~ 50-150 µm
  • Matrix Stable in all commonly used reagents
  • Binding/Loading Capacity (μmol Me2+/ml gel) 20-40
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