High Density Cobalt

Cobalt chelates recognize two exposed vicinal histidines. This resin is used in many purifications because this cation provides very good selectivity.High Density Cobalt provides a high amount of available groups allowing for higher binding capacity.The resin is adequate to work in batch or column purifications (Low Flow).

REFERENCES:

Muñoz-Morales, Emilio et al. “Deciphering the Effect of Microbead Size Distribution on the Kinetics of Heterogeneous Biocatalysts through Single-Particle Analysis Based on Fluorescence Microscopy.” Catalysts 9.11 (2019): n. pag. Catalysts.
Anderson, Cathy J. et al. “Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.” Cell Reports 26.7 (2019): 1681-1690.e5. Cell Reports.

Product Name High Density Cobalt

Cat. No. 6BCL-QHCo-X

Bead Geometry & Size Spherical ~50 - 150 µm

Crosslinked Yes

Agarose % 6 %

Antimicrobial Agent 20% Ethanol

Storage Temperature 2-8˚C

Matrix Stable in all commonly used reagents

Binding/Loading Capacity (μmol Me2+/ml gel) 20-40