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Ion Exchange Chromatography with Agarose Beads in Antibody Purification
ABT agarose beads provide reliable performance in ion exchange chromatography, ensuring high protein binding, precise separation of charge variants, and reproducible results from lab-scale analysis to industrial antibody purification.
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ABT at Analytica 2026: Advancing Bioprocessing Innovation in Munich
From March 24–27, ABT will be showcasing its expertise in agarose-based resins and custom chromatography solutions at Analytica 2026 in Munich, Germany. Visit us to explore how our advanced purification technologies can support scalable and high-quality bioprocess workflows. Our team will be on-site to discuss tailored solutions designed for pharmaceutical and biotech leaders seeking robust, reproducible, and high-performance results.
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ABT to Attend Bioprocessing Summit Europe 2026: High-Performance Agarose Resins for Downstream Processing
ABT will attend Bioprocessing Summit Europe 2026 in Barcelona. Discover how our agarose chromatography resins support scalable, robust downstream processing from early development to GMP manufacturing.
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Next Stop: BPI Boston 2025!
ABT returns to Bioprocess International Boston, where the future of bioprocessing from cell line and cell culture to downstream and next generation manufacturing, is showcased.
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Biotechnology and pharmaceutical companies often rely on standard products for biomolecule purification and immobilization.
However, when higher performance, improved efficiency, or project-specific adaptations are required, standard solutions may no longer be sufficient. In such cases, customized resins become essential, enabling processes to meet unique requirements while surpassing conventional results. ).
At Agarose Bead Technologies (ABT), one of our hallmarks over the past 25 years has been providing customized services in close collaboration with our partners, ensuring that their projects are not only feasible but also stand out in terms of process efficiency, cost-effectiveness, and quality.
CUSTOMIZATION APPROACH
Custom resin development requires close collaboration between manufacturer and customer. The process typically follows four key phases, from initial discussions to full-scale manufacturing under stringent quality standards.
Phase 1: Project starts (1h)
• Technical discussion and definition of the Development Plan (target product profile, bead characteristics, volumes, quality parameters).
• NDA signed to ensure mutual confidentiality and trust.
Phase 2: Evaluation of the viability (1-2 weeks)
• Evaluation of technical and economic viability.
• Prototype quotation (minimum trial quantity) and bulk price estimation.
Phase 3: Project starts (4-6 weeks)
• Prototype resin delivered for customer testing.
• If required, ABT can perform preliminary testing as a service to accelerate early development phases
Phase 4: Evaluation of the viability (3-6 months)
• Manufacturing scale-up, process validation, and preparation of a Regulatory Support File (RSF).
• Production under ISO 9001:2015 ensuring traceability, consistency, and compliance.
Figure 1. Adjustable parameters to meet specific requirements.
CASE STUDY: A HIGH-CAPACITY AND ALKALI-RESISTANT PROTEIN A AGAROSE RESIN
In response to a customer’s demand for a Protein A resin that combined exceptional binding capacity with enhanced resistance to sodium hydroxide (NaOH) during cleaning-in-place (CIP) procedures, our team developed a custom-engineered solution using a Design of Experiments (DoE) strategy.
This systematic approach allowed the simultaneous optimization of three critical parameters:
• Protein A ligand – to maximize affinity and capacity.
• Agarose backbone matrix – to ensure mechanical robustness and stability.
• Coupling method – to achieve optimal ligand density and chemical resilience.
The resulting prototype exhibited a significantly higher Dynamic Binding Capacity (DBC), even at reduced residence times, while preserving excellent alkaline stability (Figure 2).
Figure 2. Comparison of DBC10 versus residence time between the customized prototype (blue) and a commercial benchmark resin (orange).
This outcome highlights how our customization service enables the joint development of tailored chromatographic solutions, working closely with customers to rapidly address specific process requirements and accelerate biopharmaceutical purification workflows.